Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.
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چکیده
منابع مشابه
5-Hydroxytryptamine levels and platelet aggregation responses in subjects with acute migraine headache.
Blood 5-hydroxytryptamine levels were reduced during migraine attacks in patients who had not taken any drugs but the aggregation responses to 5-hydroxytryptamine of the blood platelets from these patients were similar to responses of platelets from migrainous subjects between attacks. This confirms earlier findings that a permanent difference exists in the behaviour of platelets from migrainou...
متن کاملAn assessment of platelet aggregation induced by 5-hydroxytryptamine.
A method of expressing platelet aggregation response after incubation relative to the response before incubation has been used in preference to using direct measurements, and some reasons are given for this choice. The effect of pre-incubating human platelets with reserpine has been compared with the effect of pre-incubation with 5-hydroxytryptamine (5HT). Reserpine inhibited 5HT-induced aggreg...
متن کاملRepeated chlorpromazine administration increases a behavioural response of rats to 5-hydroxytryptamine receptor stimulation.
1 The hyperactivity syndrome produced in rats by administration of tranylcypromine (20 mg/kg i.p.) followed 30 min later by L-tryptophan (50 mg/kg i.p.) is generally considered to be due to increased 5-hydroxytryptamine (5-HT) functional activity. It is inhibited by chlorpromazine (30 mg/kg i.p.) injected 60 min before the tranylcypromine. However, chlorpromazine injection for 4 days either at ...
متن کاملThe Influence of Chlorpromazine on the Metabolism of 5-hydroxytryptamine in the Mouse.
The aim of the present experiments was to clarify the influence of chlorpromazine on 5-hydroxytryptamine (5HT) in mouse brain. It was shown earlier (Bartlet, 1960) that the injection of iproniazid into mice produced an accumulation of cerebral 5HT, and that the rate of accumulation of the amine was reduced by chlorpromazine. It was suggested that chlorpromazine reduced the rate of formation of ...
متن کاملAggregation of Blood Cells by 5-hydroxytryptamine (serotonin).
• A rapid, reproducible method of determiniEg the presence and relative amounts of adhesive and aggregated blood elements in the blood has recently been developed in this laboratory.The method involves measuring the pressure required to force blood at a constant rate through a standardized screen with multiple openings 20 micra square and 20 micra deep. This pressure has been named "screen nitr...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1975
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1975.tb00468.x